Duke addressed the "Review of the Holocaust: Global Vision" conference hosted by Iran's president Mahmoud Ahmadinejad in Tehran on December 11, 2006. At the Tehran conference, Duke's institutional affiliation was given as MAUP, a private Ukrainian university with close links to the Iranian regime and the main publisher of anti-Semitic material in Ukraine.

In his remarks, listed on the event program as "A Holocaust Enquiry," Duke reiterated his view that Zionists control and manipulate governments, politics and media in the Western world. He stated, "I know that the Zionist extremists lead my country to catastrophe in the Mideast and elsewhere around the world. I know that the Palestinian people, the Lebanese people, even the American people have been sacrificed on the altar of the Holocaust."

As proof that the US State Department is "under thorough control of International Zionism" Duke cited the agency's statement that the Tehran conference was a "disgrace." He also maintained that repeated media references to the event as a "Holocaust denial conference" further demonstrate "Zionist control" of the media.

In the course of his comments, Duke covered a wide range of topics, most connected with politics and few having to do with the Holocaust. Topics discussed included the war in Iraq "being fought on behalf of Israel" and the imprisonment in Europe of Holocaust deniers, referred to by Duke as "scholars and researchers."